Basic Hazards

Dose

Routes of Entry

Effects

Local vs Systemic

Measures

Classification

Physiological Classification of Toxic Responses

Toxic substances can be classified according to the physiological effects they have on the human body. This classification scheme separates toxic substances into the following categories:

ClassEffect
Irritant: Causes inflammation of the skin and mucous membranes (skin, eyes, nose, or respiratory system).
Corrosive: A material that can destroy human tissue. Includes both acids and bases and may be a solid liquid or gas. Most common toxic material encountered in the laboratory.
Asphyxiant: A material that deprives tissue of oxygen and causes suffocation by displacing oxygen or interfering chemically with oxygen absorption, transport or utilization.
Anesthetic: Depresses the central nervous system Example: alcohols, halogenated hydrocarbons
Hepatotoxin: causes liver damage. Example: carbon tetrachloride
Nephrotoxin: causes kidney damage. Example: chloroform, mercury, dimethyl sulfate
Neurotoxin: affects the nervous system. Example:mercury, lead, carbon disulfide
Hematopoietic toxin: affects the cellular components of blood or its ability to function Example: benzene, xylene, CO, cyanides
Pulmonary toxin: irritates or damages the lungs. Example: asbestos, silica ozone. chromium
Reproductive toxins: causes impotence or sterility in men and women. Example: lead, dibromodichloropropane
Carcinogen: A material which can cause cancer. Example: asbestos, Bis-chloromethyl ether, benzene, acrylonitrile
Mutagen: Anything which causes a change in the genetic material of a living cell. Many mutagens are also carcinogens.
Teratogen: A material which interferes with the developing embryo when a pregnant female is exposed to that substance. Example: lead, thalidomide