PPE

Skin surfaces which might be exposed to these substances during routine operations or foreseeable accidents should be covered with appropriate protective clothing. Chemically resistant gloves (not common lab latex gloves) should be worn whenever transferring or handling these substances. The level of eye protection should be based on splash risk and may include safety glasses, goggles or a face shield in addition to goggles. Impermeable outer garments (such as aprons) should be used when performing procedures with a high splash potential. When wearing washable garments (such as a laboratory coat), evaluate the potential for exposing non-laboratory personnel (and placing them at risk) during the laundering process. Wear disposable garments if others may be placed at risk during the laundering process. Consider using full body protection (disposable chemically resistant coveralls) if the potential for extensive personal contamination exists.

All protective equipment should be removed when leaving the designated area and decontaminated (washed) or, if disposable, placed in a plastic bag and secured. Call the Occupational Health and Safety Section for disposal instructions. Skin surfaces, hands, forearms, face and neck should be washed immediately.

Procedures

	Use these chemicals only in a chemical fume hood or other appropriate containment device (glove box). If a chemical fume hood is used it should be evaluated to confirm that it is performing adequately (a face velocity of at least 100 linear feet per minute (±20%) with the sash at the operating height).
	All procedures with these chemicals should be performed in designated areas. A chemical fume hood can be considered a designated area. Other employees working in the area should be informed of the particular hazards associated with these substances and the appropriate precautions that are necessary for preventing exposures. All designated areas should be posted with a sign which reads: WARNING DESIGNATED AREA FOR HANDLING THE FOLLOWING SUBSTANCES WITH HIGH ACUTE OR CHRONIC TOXICITY: [list of substances - identify acute or chronic hazard] [Example: Benzene - carcinogen] AUTHORIZED PERSONNEL ONLY
	Volatile chemicals should be transported between laboratories in durable outer containers.
	Vacuum pumps used in procedures should be protected from contamination by installing two collection flasks in series along with in-line HEPA-like filter
	Analytical instruments or other laboratory equipment generating vapors and/or aerosols during their operation, should be locally exhausted or vented in a chemical fume hood.
	Work surfaces on which these substances will be handled should be covered with an easily decontaminated surface (such as stainless steel) or protected from contamination with plastic trays or plastic backed paper. Call the Occupational Health and Safety Section for decontamination and disposal procedures; these will be substance specific. Materials that will be disposed of should be placed in plastic bags and secured.
	Chemical wastes from procedures using these substances should be placed in containers, tagged and disposed of through the Environmental Services Section hazardous chemical waste program. The wastes should be stored in the designated area (defined above) meeting all requirements of a laboratory hazardous waste satellite accumulation area.
	Normal laboratory work should not be conducted in a designated area until it has been decontaminated or determined to be acceptable by the principal investigator, laboratory supervisor or Occupational Health and Safety Section. Call the Occupational Health and Safety Section for decontamination procedures.
	If one or more of these substances are used in large quantities, on a regular basis (three or more separate handling sessions per week), or for long periods of time (4-6 hours) a qualitative and potentially quantitative exposure assessment should be performed. Contact the Occupational Health and Safety Section to perform this assessment.
	The Occupational Health and Safety Section in conjunction with the Employee Health Physician will determine if it is appropriate to establish an ongoing medical surveillance program.
	Lab personnel of childbearing age should be informed of any known male and female reproductive toxins used in the lab. An employee who is pregnant, or planning to become pregnant, and who is working with potential reproductive toxins that might affect the fetus, should contact the Occupational Health and Safety Section to evaluate their exposure and inform the Employee Health Physician and her personal physician of the particular substance being used as necessary. The Occupational Health and Safety Section can assess potential exposures and work with the principal investigator or laboratory supervisor, if necessary, to adjust work practices to minimize the potential risk.

Storage

Volatile chemicals should be stored in a vented storage area in an unbreakable, primary or secondary container and placed in a chemically resistant tray (to contain spills). Nonvolatile chemicals should be stored in cabinets or in drawers. Do not store these chemicals on open shelves or counters. Access to these chemicals should be restricted.